ea0070aep230 | Bone and Calcium | ECE2020
Mazziotti Gherardo
, Rodari Marcello
, Pepe Giovanna
, Gelardi Fabrizia
, Zucali Paolo
, Chiti Arturo
Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). The determinants of this effect are unknown and it is still unclear whether Radium-223 may induce skeletal fragility regardless of other therapies of CRPC. We aimed at evaluating the incidence and determinants of vertebral fractures (VFs), i.e. the hallmark of skeletal fragility, in CRCP patients undergoing Radium-223 therapy in the real-life c...